[time 1094] Re: Proteins as unconscious computers


Matti Pitkänen (matpitka@pcu.helsinki.fi)
Tue, 7 Dec 1999 08:46:09 +0200


Dear Lawrence,

As you mentioned banana plant has genome which
is 10^5 times longer than human genome. Should
provide food for critical thought!

The huge amount of plant genome has simple explanation
using the concept of manysheeted DNA implying
automatically subprogram hierarchy. Plant genome
is simply a poorly modularized program. Same
small submodules are written again and again.

I can even identify the p-adic spacetime sheet
in question: p=about 2^k, k=167, the p-adic length
scale of cell. Modularization stops
at k=167 level. No higher level modules are used.
In case of animals modularization continues to
k=169,173,,,,,,levels and short programs become
possible.

The structure of genome should have direct anatomical
correlates if manysheeted DNA hypothesis is true.
The anatomic correlate for the stopping of modularization
is the formation of cells walls: it made impossible the
formation of epithelials sheets (k=169) and higher
level organs.

I also understood junk DNA. Introns inside gene
are nothing but unused subprogram calls
with comment sign added in front of them.
previously existing gene sequence becomes
a new submodule calling sequence of submodules.
There are however some submodules which are
not needed and these are "comment-signed" so that
they become introns.

 What is fascinating that the number of introns in gene
allows to deduce the number of subprograms convoluted by gene
to single program. The proteins coding these
genes should have modular structure
and perhaps the gene activated by them
would be formed in similar manner from
genes called by exons in gene. Stringent
prediction!

I learned also that there are also "inteins":
proteins containing nonfunctional parts (kind
of loop insertions?). This is alternative possibility
to "comment-sign". There are also
pseudogenes which do not code any
protein. They contain usually programming
error (like two stopping signs). This is
a manner to "comment-sign" entire gene.

With Best,
MP
 



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